مجلة جامعة الزيتونة الدولية للنشر العلمي مجلة علمية، محكمة، شهرية، مفتوحة الوصول
Abstract
Objectives: This study aims to evaluate the relationship between hypertension and diabetes with an increased risk of early kidney function impairment, as well as to assess the performance of the albumin-to-creatinine ratio (ACR) as a diagnostic criterion in this patient group. Methods: The study included 108 participants (males and females) aged between 30 and 80 years. Participants were divided into groups based on their health conditions: hypertensive patients, diabetic patients, those with both conditions, and a control group. Mean and standard deviation (mean ± SD) were calculated, along with the predictive ability of the ACR test. Results: The analyses revealed significant differences in several health parameters, with notable increases in blood sugar levels, HbA1C, and systolic and diastolic blood pressure in the diabetes and hypertension groups compared to the control group, with strong statistical significance (P<0.001). Additionally, a significant increase in the albumin-to-creatinine ratio (ACR) was observed, indicating potential deterioration in kidney function. The study also identified important positive and negative correlations between ACR and factors such as age, body mass index (BMI), and kidney function. The ACR test’s ability to detect kidney impairment was evaluated, demonstrating good predictive capability with a cutoff value of > 27.59, resulting in an area under the curve (AUC) of 0.916, with a sensitivity of 92.31%, specificity of 80%, and accuracy of 85.71%. Conclusion: The ACR test demonstrated excellent performance as a diagnostic tool, highlighting the necessity for its utilization as part of a comprehensive screening strategy.
Keywords: Hypertension, Type2Diabetes, Albumin-to-Creatinine Ratio, Kidney Complications, Brack Al-Shati Hospital
اعداد :
| Amira Fatehi Akrio أميرة فتحي كريو | Prof. Bashir Mohammed Yhmed البروفيسور البشير محمد يحمد |
| قسم المختبرات الطبية – كلية التقنية الطبية – جامعة وادي الشاطئ – ليبيا | قسم المختبرات الطبية – كلية التقنية الطبية – جامعة وادي الشاطئ – ليبيا |
